Information concerning human breast cancer specific surface antigens will be obtained through the isolation and characterization of glycoproteins from human breast cancer cells and breast cancer patients' body fluids. Purified proteins will be utilized to produce specific antisera which will be used to develop sensitive immunochemical and biological assays. Techniques will be devised for the detection and localization of these components in the tumor and circulating fluids of breast cancer patients. Information concerning a possible relationship of the purified proteins to surface glycoproteins of oncornaviruses will be obtained by specific viral glycoprotein assays. Attempts to induce human breast cancer cells to produce virus or virus proteins will be made utilizing hormones and DNA analogs.